// proloTECH Services
ProloTECH is a system of regenerative injection therapy (RIT). RIT helps stimulate regeneration of tissue in painful joints. A number of different substances can be injected to help stimulate healing. All proloTECH injections are performed by a fully licensed physician (MD or DO) who is a member of the American Association of Orthopaedic Medicine and has specific training in prolotherapy and regenerative medicine.
Prolotherapy is the original form of regenerative injection therapy and the basis of modern cell-based regenerative interventions. It is used to strengthen weak or damaged ligaments which cause joint instability and pain.
An irritant solution is injected at the site of injury, causing a localized inflammatory process. This targeted inflammation results in collagen synthesis and tissue proliferation. The end result is strengthening of weak tissues and stabilization of the joint.
This basic concept can be traced back to ancient Rome when hot needles were used to help stimulate healing in the shoulders of injured Gladiators. The modern form of prolotherapy began in the 1950's with the work of Dr. George Hackett and Dr. Gustav Hemwall.
Today, prolotherapy is used to treat acute injuries and chronic pain. The most common injectate is a hypertonic dextrose solution mixed with a small amount of local anesthetic. This is an inexpensive option that is highly effective for a wide range of orthopedic problems, making regenerative injection therapy available to everyone.
Prolotherapy requires a detailed knowledge of musculoskeletal anatomy and a mastery of injection techniques. It can be used alone or in combination with more advanced cell and tissue based therapies.
PLATELET RICH PLASMA
Platelets are small cell fragments derived from the megakaryocytes in bone marrow. They circulate in whole blood where they participate in hemostasis and tissue regeneration. When tissues are injured, platelets aggregate at the site of injury and form a blood clot to stop the bleeding.
After formation of a clot, platelets are "activated." When activated, they release granules containing dozens of powerful growth factors that aid in regeneration of injured tissues. Platelet growth factors include Platelet Derived Growth Factor (PDGF), Transforming Growth Factor (TGF), Platelet-Derived Angiogenesis Factor (PDAF), and many others.
To obtain platelets for use in regenerative injection therapy, a patient's blood is drawn and placed in a centrifuge. The centrifuge spins the blood sample at a very high speed to separate the blood and to isolate the platelets. Platelets are then condensed into a plasma fraction that has five to seven times the platelet concentration of regular whole blood.
This "platelet-rich plasma" (PRP) is then reinjected directly into injured tissues. Release of the platelet growth factors stimulates regeneration, promoting recovery from injury. PRP is very easy to obtain and it is a very effective form of regenerative injection therapy
AUTOLOGOUS BONE MARROW CONCENTRATE
For more complicated injuries, autologous Bone Marrow Concentrate (BMC) can be taken from the iliac crest (hip bone) and used for regenerative injection therapy. Local anesthetic is used to minimize pain and discomfort. BMC is injected at the site of injury to help stimulate regeneration of injured or degenerative tissues. BMC contains a number of cellular elements that aid in the regenerative process, including mesenchymal stem cells. BMC is not required for most cases, but when used it can be one of the most powerful tools in outpatient regenerative medicine.
"Prolozone" is the use of ozone gas in regenerative injection therapy. While often used alone, it is only offered by proloTECH as an adjunct to other therapies. Ozone theoretically works by way of a transient oxidative stress that activates platelets and white blood cells. When used in conjunction with other injection therapies, ozone demonstrates anti-inflammatory, anti-microbial, and immunomodulatory effects that can enhance the regenerative response to treatment.